Authors: Perez-Rizquez, C; Rodriguez-Otero, A; Palomo, JM

Org. Biomol. Chem.. vol: 17. page: 1477-0520.
Date: AUG 14. 2019.
Doi: 10.1039/c9ob01091b.

This review describes the recent advances in the design of novel artificial metalloenzymes and their application in C-H activation reactions. The combination of enzymes and metal or organometallic complexes for the creation of new artificial metalloenzymes has represented a very exciting research line. In particular, the development of proteins with the ability to perform C-H functionalization presents a significant challenge. Here we discuss the development of these processes on natural metalloenzymes by using directed evolution, biotin-(strept)avidin technologies, photocatalytic hybrids or reconstitution of heme-protein technology..