Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling

Autores: David Gonzalez-Perez, Satyajit Das, Daniel Antfolk, Hadia S. Ahsan, Elliot Medina, Carolyn E. Dundes, Rayyan T. Jokhai, Emily D. Egan, Stephen C. Blacklow, Kyle M. Loh, Paulo C. Rodriguez & Vincent C. Luca

Nature Chemical Biology. 19, pages9–17
Fecha: sept. 2022
Doi: 10.1039/d2se01073a.


The Notch pathway regulates cell fate decisions and is an emerging target for regenerative and [read more]

Highly Active and Stable Ni/La-Doped Ceria Material for Catalytic CO2 Reduction by Reverse Water-Gas Shift Reaction

Autores: Consuelo Alvarez-GalvanPablo G. LustembergFreddy E. OropezaBelén Bachiller-BaezaMartin Dapena OspinaMaría HerranzJesús CebolladaLaura Collado, José M. Campos-MartinVíctor A. de la Peña-O’SheaJosé A. Alonso, and M. Verónica Ganduglia-Pirovano.

ACS Appl. Mater. Interfaces
Fecha: oct-03. 2022.

he design of an active, effective, and economically viable catalyst for CO2 conversion [read more]

2022-11-03T14:38:51+01:00Categories: Destacados, Publicaciones 2022|

Switch off/switch on of a cysteinyl protease as a way to preserve the active catalytic group by modification with a reversible covalent thiol modifier: Immobilization of ficin on vinyl-sulfone activated supports

Autores: Morellon-Sterling, R; Bolivar, JM; Fernandez-Lafuente, R

Int. J. Biol. Macromol.. vol: 220. page: 0141-8130.
Fecha: nov-01. 2022.
Doi: 10.1016/j.ijbiomac.2022.08.155.

The immobilization of ficin (a cysteinyl proteases) on vinyl sulfone agarose produced its almost full inactivation. It was observed that the incubation of the free and immobilized enzyme in beta-mercaptoethanol produced a 20 % of enzyme activity recovery, suggesting that [read more]

Sulfur-doped carbon nanofibers as support for tantalum oxides bifunctional catalysts for the oxygen reduction and evolution reactions

Autores: Ruiz-Cornejo, JC; Sebastian, D; Pardo, JI; Martinez-Huerta, MV; Lazaro, MJ

J. Power Sources. vol: 546. page: 0378-7753.
Fecha: oct-30. 2022.
Doi: 10.1016/j.jpowsour.2022.231988.

Highly efficient, low-cost and stable bifunctional catalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are highly desirable for the development of green electrochemical energy storage and conversion devices. Here, we report the synthesis of [read more]

A Plurizyme with Transaminase and Hydrolase Activity Catalyzes Cascade Reactions

Autores: Roda, S; Fernandez-Lopez, L; Benedens, M; Bollinger, A; Thies, S; Schumacher, J; Coscolin, C; Kazemi, M; Santiago, G; Gertzen, CGW; Gonzalez-Alfonso, JL; Plou, FJ; Jaeger, KE; Smits, SHJ; Ferrer, M; Guallar, V

Angew. Chem.-Int. Edit.. vol: 61. page: 1433-7851.
Fecha: sep-12. 2022.
Doi: 10.1002/anie.202207344.

Engineering dual-function single polypeptide catalysts with two abiotic or biotic catalytic entities (or combinations of [read more]

Lipase immobilization via cross-linked enzyme aggregates: Problems and prospects – A review

Autores: Sampaio, CS; Angelotti, JAF; Fernandez-Lafuente, R; Hirata, DB

Int. J. Biol. Macromol.. vol: 215. page: 0141-8130.
Fecha: AUG 31. 2022.
Doi: 10.1016/j.ijbiomac.2022.06.139.

In this review we have focused on the preparation of cross-linked enzyme aggregates (CLEAs) from lipases, as these are among the most used enzyme in bioprocesses. This immobilization method is considered very attractive due to preparation simplicity, [read more]

Recent progress in the quantitative assessment and interpretation of photoactivity

Autores: Caudillo-Flores, U; Munoz-Batista, MJ; Fernandez-Garcia, M; Kubacka, A

Review; Early Access.
Catal. Rev.-Sci. Eng.. vol: . page: 0161-4940.
Fecha: . .
Doi: 10.1080/01614940.2022.2075535.

The development of the photo-catalysis field is limited by a deficient quantitative assessment of photo-activity. The interplay between mass and momentum transport together with radiative transfer phenomena taking place at any photo-catalytic reaction or process makes complex [read more]

2022-07-15T11:26:06+02:00Categories: Destacados, Publicaciones 2022|Tags: , |

Enzyme immobilization strategies for the design of robust and efficient biocatalysts

Autores: Guisan, JM; Fernandez-Lorente, G; Rocha-Martin, J; Moreno-Gamero, D

Curr. Opin. Green Sustain. Chem.. vol: 35. page: 2452-2236.
Fecha: JUN. 2022.
Doi: 10.1016/j.cogsc.2022.100593.

Different strategies for the preparation of efficient and robust immobilized biocatalysts are here reviewed. Different physico-chemical approaches are discussed. i.-The stabilization of enzyme by any kind of immobilization on pre-existing porous supports. ii.-The stabilization of enzymes by [read more]

Transformation of CoFe2O4 spinel structure into active and robust CoFe alloy/N-doped carbon electrocatalyst for oxygen evolution reaction

Autores: Gebreslase, GA; Martinez-Huerta, MV; Sebastian, D; Lazaro, MJ

J. Colloid Interface Sci.. vol: 625. page: 0021-9797.
Fecha: NOV. 2022.
Doi: 10.1016/j.jcis.2022.06.005.

Electrochemical water splitting is an environmentally benign technology employed for H-2 production; however, it is critically hampered by the sluggish kinetics of the oxygen evolution reaction (OER) at the positive electrode. In this work, nitrogen-doped carbon-coated CoFe electrocatalysts [read more]

2022-07-15T11:10:00+02:00Categories: Destacados, Publicaciones 2022|Tags: , |

Eco-friendly mechanochemical synthesis of titania-graphene nanocomposites for pesticide photodegradation

Autores: Gonzalez, VJ; Vazquez, E; Villajos, B; Tolosana-Moranchel, A; Duran-Valle, C; Faraldos, M; Bahamonde, A

Sep. Purif. Technol.. vol: 289. page: 1383-5866.
Fecha: may-15. 2022.
Doi: 10.1016/j.seppur.2022.120638.

Titania graphene hybrid nanocomposites (TiO2-FLG) synthesized from graphite and TiO2 precursors, in a simple and sustainable approach via a three-step method, including the mechanochemical treatment of pre-synthesized FLG and TiO2 NPs are efficient [read more]

2022-06-08T09:23:05+02:00Categories: Destacados, Publicaciones 2022|Tags: , |


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