Authors: Luz, EPCG; Borges, MD; Andrade, FK; Rosa, MD; Infantes-Molina, A; Rodriguez-Castellon, E; Vieira, RS

Cellulose. vol: 25. page: 0969-0239.
Date: NOV. 2018.
Doi: 10.1007/s10570-018-2008-8.

Hybrid materials (HMs) based on a combination of bacterial cellulose (BC) and hydroxyapatite (HA) have demonstrated promising capabilities, especially for bone repair. The insertion of strontium into a BC/HA matrix has a role in the body related to bone remodeling. This study aimed to obtain HMs containing BC/HA doped with strontium ions (Sr2+) by two routes of synthesis, differing in the way strontium was inserted. The HMs produced were characterized to elucidate the morphology and metal/biopolymer interaction, and also strontium adsorption/desorption profiles were evaluated. The biomaterials produced were able to interact with Sr2+, showing a distinct adsorption/desorption profile for each material. BC/CaHA/Sr showed an ion exchange between Ca2+ present in hydroxyapatite by the Sr2+ in solution, characterized by mainly a physisorption mechanism. BC/SrAp demonstrated a chemical bond of Sr2+ on the BC surface by a chemisorption mechanism. The desorption study showed that the Sr release reached a plateau after 11 and 60days and after 4months, 91 and 6% of the adsorbed Sr2+ was released by BC/CaHA/Sr and BC/SrAp, respectively. These results suggest that the delivery of Sr2+ can be modulated during bone repair depending on the way Sr2+ is inserted into the hybrid matrix. [GRAPHICS] ..