Organic

Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C-H activation chemistry

Authors: Perez-Rizquez, C; Rodriguez-Otero, A; Palomo, JM

Review.
Org. Biomol. Chem.. vol: 17. page: 1477-0520.
Date: AUG 14. 2019.
Doi: 10.1039/c9ob01091b.

Abstract:
This review describes the recent advances in the design of novel artificial metalloenzymes and their application in C-H activation reactions. The combination of enzymes and metal or organometallic complexes for the creation of new artificial metalloenzymes has represented a very [read more]

2020-05-04T12:47:12+02:00Categories: Publications 2019|Tags: , |

Benchmarking of laboratory evolved unspecific peroxygenases for the synthesis of human drug metabolites

Authors: de Santos, PG; Cervantes, FV; Tieves, F; Plou, FJ; Hollmann, F; Alcalde, M

Article.
Tetrahedron. vol: 75. page: 0040-4020.
Date: mar-29. 2019.
Doi: 10.1016/j.tet.2019.02.013.

Abstract:
By mimicking the role of human liver P450 monooxygenases, fungal unspecific peroxygenases (UPOs) can perform a range of highly selective oxyfunctionalization reactions on pharmacological compounds, including O-dealkylations and hydroxylations, thereby simulating drug metabolism. Here we have [read more]

2020-05-04T12:50:31+02:00Categories: Publications 2019|Tags: , |

Lipase Regioselective O-Acetylations of a myo-Inositol Derivative: Efficient Desymmetrization of 1,3-Di-O-benzyl-myo-inositol

Authors: Ribeiro, MFP; Pais, KC; de Jesus, BSM; Fernandez-Lafuente, R; Freire, DMG; Manoel, EA; Simas, ABC

Article.
Eur. J. Org. Chem.. vol: . page: 1434-193X.
Date: JAN 23. 2018.
Doi: 10.1002/ejoc.201701417.

Abstract:
Chiral myo-inositol derivatives play key roles in cell-signaling processes. Despite the relevance of these compounds, few syntheses of them rely on enantioselective catalytic reactions. Even fewer reports describe the use [read more]

2020-05-29T10:52:55+02:00Categories: publications2018|Tags: , |

Calendar

February 2021
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
Go to Top