Pd-Oxazolone complexes conjugated to an engineered enzyme: improving fluorescence and catalytic properties

Authors: Garcia-Sanz, C; Andreu, A; de las Rivas, B; Jimenez, AI; Pop, A; Silvestru, C; Urriolabeitia, EP; Palomo, JM

Article.
Org. Biomol. Chem.. vol: 19. page: 1477-0520.
Date: mar-28. 2021.
Doi: 10.1039/d1ob00305d.

Abstract:
Different Pd-complexes containing orthometallated push-pull oxazolones were inserted by supramolecular Pd-amino acid coordination on two genetically engineered modified variants of the thermoalkalophilic Geobacillus thermocatenolatus lipase (GTL). Pd-lipase conjugation was [read more]

2021-03-28T00:00:00+01:00Categories: Publications 2021|Tags: , |

Palladium Nanocatalysts for Cascade C-N Cross-Coupling/Heck Reaction

Authors: Rodriguez-Oliva, I; Losada-Garcia, N; Santos, AS; Marques, MMB; Palomo, JM

Article; Early Access.
Asian J. Org. Chem.. vol: . page: 2193-5807.
Date: . .
Doi: 10.1002/ajoc.202100077.

Abstract:
Highly stable nanocatalysts have been synthesized in aqueous medium at room temperature by the in situ formation of Pd nanoparticles (PdNPs) embedded in an enzyme net. Different parameters in the synthesis were evaluated such [read more]

2021-04-08T12:17:35+02:00Categories: Publications 2021|Tags: , |

Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C-H activation chemistry

Authors: Perez-Rizquez, C; Rodriguez-Otero, A; Palomo, JM

Review.
Org. Biomol. Chem.. vol: 17. page: 1477-0520.
Date: AUG 14. 2019.
Doi: 10.1039/c9ob01091b.

Abstract:
This review describes the recent advances in the design of novel artificial metalloenzymes and their application in C-H activation reactions. The combination of enzymes and metal or organometallic complexes for the creation of new artificial metalloenzymes has represented a very [read more]

2020-05-04T12:47:12+02:00Categories: Publications 2019|Tags: , |

Benchmarking of laboratory evolved unspecific peroxygenases for the synthesis of human drug metabolites

Authors: de Santos, PG; Cervantes, FV; Tieves, F; Plou, FJ; Hollmann, F; Alcalde, M

Article.
Tetrahedron. vol: 75. page: 0040-4020.
Date: mar-29. 2019.
Doi: 10.1016/j.tet.2019.02.013.

Abstract:
By mimicking the role of human liver P450 monooxygenases, fungal unspecific peroxygenases (UPOs) can perform a range of highly selective oxyfunctionalization reactions on pharmacological compounds, including O-dealkylations and hydroxylations, thereby simulating drug metabolism. Here we have [read more]

2020-05-04T12:50:31+02:00Categories: Publications 2019|Tags: , |

Lipase Regioselective O-Acetylations of a myo-Inositol Derivative: Efficient Desymmetrization of 1,3-Di-O-benzyl-myo-inositol

Authors: Ribeiro, MFP; Pais, KC; de Jesus, BSM; Fernandez-Lafuente, R; Freire, DMG; Manoel, EA; Simas, ABC

Article.
Eur. J. Org. Chem.. vol: . page: 1434-193X.
Date: JAN 23. 2018.
Doi: 10.1002/ejoc.201701417.

Abstract:
Chiral myo-inositol derivatives play key roles in cell-signaling processes. Despite the relevance of these compounds, few syntheses of them rely on enantioselective catalytic reactions. Even fewer reports describe the use [read more]

2020-05-29T10:52:55+02:00Categories: publications2018|Tags: , |

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