Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase
Authors: Cea-Rama, I; Coscolin, C; Katsonis, P; Bargiela, R; Golyshin, PN; Lichtarge, O; Ferrer, M; Sanz-Aparicio, J
Comp. Struct. Biotechnol. J… vol: 19. page: 2001-0370.
Date: . 2021.
Our understanding of enzymes with high substrate ambiguity remains limited because their large active sites allow substrate docking freedom to an extent that seems incompatible with stereospecificity. One possibility is [read more]